And lastly, clonidine enhances neuraxial opioids and, together with fentanyl, interacts within an additive manner, which can lessen the dose of each and every part by 60% for postoperative analgesia.Jun 10, 2024 · If clonidine therapy will be to be replaced by a β-blocker, delay administration on the β-blocker for many times soon after clonidin